BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 756K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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24 articles for JI Trujillo

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.EBI
Pfizer
Design and synthesis of novel CCR2 antagonists: investigation of non-aryl/heteroaryl binding motifs.EBI
Pfizer
Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).EBI
Pfizer
Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa.EBI
Pfizer
Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists.EBI
Pfizer
Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.EBI
Pfizer
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).EBI
Pfizer
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.EBI
Pfizer
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.EBI
Pfizer
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.EBI
Karo Pharma
Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.EBI
Pfizer
BIFUNCTIONAL FOLATE RECEPTOR BINDING COMPOUNDSBDB
Lycia Therapeutics
AZA-ERGOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOFBDB
Shanghaitech University
COMPOUNDS AND METHODS FOR MODULATING FXRBDB
Terns Pharmaceuticals
5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCERBDB
Astrazeneca
Substituted imidazo[1,5-a]pyrazines for IRE1 inhibitionBDB
Optikira
Compounds for the treatment of painBDB
TBA
Inhibitors of bruton's tyrosine kinaseBDB
Hoffmann-La Roche
TYK2 inhibitors and uses thereofBDB
Nimbus Lakshmi
Benzolactam compounds as protein kinase inhibitorsBDB
Otsuka Pharmaceutical
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activityBDB
Boehringer Ingelheim International
Trifluoromethyl pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereofBDB
Lycera
Overview of the SAMPL5 host-guest challenge: Are we doing better?BDB
University of California San Diego
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.BDB
University of Massachusetts Medical School