86 articles for JY Lee
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Article Title
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3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes.
Kyung Hee University
Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R.
Korea Research Institute of Chemical Technology
Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents.
Kyung Hee University
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.
Korea Research Institute of Chemical Technology
Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study.
Kyung Hee University
3-Benzamides and 3,4,5-trimethoxyphenyl amines as calcium channel blockers.
Ewha Womans University
Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.
Seoul National University
Synthesis and PGE2 production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells.
TBA
Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors.
Korea Research Institute of Chemical Technology
Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist.
Kyung Hee University
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.
Kyung Hee University
Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid.
Kyung Hee University
3D QSAR studies on 3,4-dihydroquinazolines as T-type calcium channel blocker by comparative molecular similarity indices analysis (CoMSIA).
Kyung Hee University
3D-QSAR studies on sildenafil analogues, selective phosphodiesterase 5 inhibitors.
Sungkyunkwan University
Synthesis and In Vitro evaluation of fused ring heterocyle-containing angiotensin II antagonists.
TBA
Identification of novel mPGES-1 inhibitors through screening of a chemical library.
Kookmin University
Chemical modulators working at pharmacological interface of target proteins.
Korea University College of Pharmacy Sejong-Ro
Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers.
Korea Institute of Science & Technology
N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Seoul National University
Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides.
Institute of Science and Technology
Synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives as losartan analogue for new angiotensin II receptor type 1 (AT1) antagonists.
Kyung Hee University
In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor.
Kyung Hee University
Discovery of DA-1229: a potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.
Dong-A Pharm.
Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells.
Pusan National University
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling.
New York University
Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitors.
Amorepacific
Synthesis and PGE(2) production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives.
Kyung Hee University
Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists.
Institute of Science & Technology
Design, synthesis, screening, and molecular modeling study of a new series of ROS1 receptor tyrosine kinase inhibitors.
University of Science and Technology
Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor.
Kyung Hee University
Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors.
Institute of Science and Technology
Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics.
Konkuk University
Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers.
Institute of Science and Technology
T-type Ca2+ channel blockers suppress the growth of human cancer cells.
Kyung Hee University
Discovery of novel amidobenzimidazole derivatives as orally available small molecule modulators of stimulator of interferon genes for cancer immunotherapy.
Korea Research Institute of Chemical Technology
Synthesis of bitopic ligands based on fallypride and evaluation of their affinity and selectivity towards dopamine D2 and D3 receptors.
University of Pennsylvania
7-Amino-3-phenyl-2-methyl-pyrazolopyrimidine derivatives inhibit human rhinovirus replication.
Korea Research Institute of Chemical Technology
Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents.
Korea Research Institute of Chemical Technology
Structure-activity relationship analysis of activity-based probes targeting HTRA family of serine proteases.
Gwangju Institute of Science and Technology
Discovery of 2-aminoquinolone acid derivatives as potent inhibitors of SARS-CoV-2.
Seoul National University
Synthesis and biological evaluation of novel T-type calcium channel blockers.
Kyung Hee University
Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor.
Korea Research Institute of Chemical Technology
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
Pharmaron Beijing
Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors.
Institute of Science & Technology
In vitro and in vivo neuroprotective effect of novel mPGES-1 inhibitor in animal model of Parkinson's disease.
Kyung Hee University
Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1.
Korea University
3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.
Institute of Science & Technology
Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis.
Cha University
Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors.
Yonsei University
Catechol-substituted L-chicoric acid analogues as HIV integrase inhibitors.
Institute of Science & Technology
Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E
Kyung Hee University
Synthesis, binding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective σ
Guangdong Medical University
Sulfamoylbenzamide-based Capsid Assembly Modulators for Selective Inhibition of Hepatitis B Viral Replication.
Korea Research Institute of Chemical Technology
In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells.
Kyung Hee University
Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors.
Korea Research Institute of Chemical Technology
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
Abbott Laboratories
Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers.
Kyung Hee University
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.
Life Science Research Center
Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.
Abbott Laboratories
6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors.
Institute of Science & Technology
Second-generation peptidomimetic inhibitors of protein farnesyltransferase demonstrating improved cellular potency and significant in vivo efficacy.
Abbott Laboratories
Discovery of a New Sulfonamide Hepatitis B Capsid Assembly Modulator.
Korea Research Institute of Chemical Technology
Adaptable Small Ligand of CYP1 Enzymes for Use in Understanding the Structural Features Determining Isoform Selectivity.
Seoul National University
Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.
Korea Research Institute of Chemical Technology
In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers.
Kyung Hee University
Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group.
Ewha Womans University
Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors.
Pusan National University
SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.
Korea Research Institute of Bioscience and Biotechnology
Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors.
In2Gen
Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.
Korea Institute of Science and Technology
Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro.
Korea Research Institute of Chemical Technology
Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.
Forma Therapeutics
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.
H�Pital Kirchberg
Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors.
Korea Research Institute of Chemical Technology
Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects.
Kyung Hee University
SMALL-MOLECULE INHIBITORS FOR BETA-CATENIN/BCELL LYMPHOMA 9 PROTEIN-PROTEIN INTERACTION
H. Lee Moffitt Cancer Center and Research Institute
Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
Nimbus Saturn
Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine.
Hebrew University of Jerusalem
Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives.
Nirma University
Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
Cayman Chemical
Aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands
Gruenenthal