17 articles for C Fernandes
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
Merck Research Laboratories
Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties.
University of Porto
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Merck Research Laboratories
Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.
Merck Research Laboratories
Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Merck Research Laboratories
4-Oxoquinolines and monoamine oxidase: When tautomerism matters.
Universit£"Magna Gr£Cia" Di Catanzaro
Mapping Chromone-3-Phenylcarboxamide Pharmacophore:
Magna Graecia University of Catanzaro
The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
Merck Research Laboratories
Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Merck Research Laboratories
Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.
Merck Research Laboratories
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.
Merck Research Laboratories
Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.
University of Porto
Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.
University of Porto
Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof
Jiangsu Hengrui Medicine
Equilibrium thermodynamics of a physiologically-relevant heme-protein complex.
University of North Carolina at Chapel Hill