Binding Database

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.

Cubist Pharmaceuticals

Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.

Cubist Pharmaceuticals

Fragment-based discovery and optimization of BACE1 inhibitors.

Evotec

Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors.

Merck & Co.

Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.

The University of Texas Md Anderson Cancer Center

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

Elixir Pharmaceuticals

Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α.

Merck

Discovery of Novel UDP-

X-Biotix Therapeutics

Structure-based discovery of LpxC inhibitors.

Cubist Pharmaceuticals

5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines

Bayer Pharma Aktiengesellschaft

The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype.

University of Notre Dame