32 articles for M Singh
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
Novartis Institutes For Biomedical Research
Synthesis of methotrexate-antibody conjugates by regiospecific coupling and assessment of drug and antitumor activities.
Dalhousie University
Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide.
Genomics Institute of Novartis Research Foundation
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.
Kurukshetra University
Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H.
Kurukshetra University
Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection.
Punjabi University
Inhibitors of switch kinase 'spleen tyrosine kinase' in inflammation and immune-mediated disorders: a review.
Punjabi University
Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs.
Mcmaster University
Structure-activity studies on seco-pancratistatin analogs: potent inhibitors of human cytochrome P450 3A4.
Mcmaster University
Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids.
Mcmaster University
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
AstraZeneca
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
Revolution Medicines
Oxindole: A chemical prism carrying plethora of therapeutic benefits.
Punjabi University
Lysophosphatidic acid (LPA) receptor modulators: Structural features and recent development.
Jss Academy of Higher Education and Research
Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-
Lupin
New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.
University of Minnesota
Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization.
Lupin
Identification of dual role of piperazine-linked phenyl cyclopropyl methanone as positive allosteric modulator of 5-HT
Csir-Central Drug Research Institute (Csir-Cdri)
Novel Tetrahydroquinazolinamines as Selective Histamine 3 Receptor Antagonists for the Treatment of Obesity.
Academy of Scientific and Innovative Research (Acsir)
Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.
Lupin
Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate.
Lupin
Purinergic receptor P2X₇: a novel target for anti-inflammatory therapy.
Punjabi University
Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.
Biota Holdings
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.
Sanofi-Aventis Deutschland
Exploration of multi-target potential of chromen-4-one based compounds in Alzheimer's disease: Design, synthesis and biological evaluations.
Punjabi University
