BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 748K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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18 articles for WE DeWolf

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.EBI
Amgen
Discovery of 2-pyridylureas as glucokinase activators.EBI
Array Biopharma
Identification of a new class of glucokinase activators through structure-based design.EBI
Array Biopharma
A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.EBI
Memorial Sloan Kettering Cancer Center
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.EBI
Array Biopharma
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.EBI
Amgen
5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties.EBI
Amgen
1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.EBI
Smithkline Beecham Pharmaceuticals
Multisubstrate inhibitors of dopamine beta-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site.EBI
TBA
Multisubstrate inhibitors of dopamine beta-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione.EBI
TBA
Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine beta-hydroxylase.EBI
TBA
Beta-substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine beta-hydroxylase.EBI
Smith Kline & French Laboratories
Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine beta-hydroxylase. 4. Structure-activity relationships at the copper binding site.EBI
Smith Kline & French Laboratories
Aniline derivative, pharmaceutical composition containing same, and use thereofBDB
Kissei Pharmaceutical
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.BDB
Dupont Pharmaceuticals
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.BDB
Glaxosmithkline
Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.BDB
Dupont Pharmaceuticals
Stereoisomers of cyclic urea HIV-1 protease inhibitors: synthesis and binding affinities.BDB
Dupont Pharmaceuticals