70 articles for H Lee
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.
University of Auckland
The discovery and the structural basis of an imidazo[4,5-b]pyridine-based p21-activated kinase 4 inhibitor.
Soongsil University
Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.
University of Illinois At Chicago
Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase.
Hebrew University-Hadassah Medical Center
Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design.
Chungnam National University
Development and biological evaluation of potent and selective c-KIT(D816V) inhibitors.
Korea Advanced Institute of Science and Technology (Kaist)
The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands.
Seoul National University
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent¿-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.
Northwestern University
Discovery of ITX 4520: a highly potent orally bioavailable hepatitis C virus entry inhibitor.
Itherx Pharmaceuticals
Discovery of new azaindole-based PI3Ka inhibitors: apoptotic and antiangiogenic effect on cancer cells.
Institute of Science and Technology (Kaist)
Prenylated xanthones from the root bark of Cudrania tricuspidata.
Chungbuk National University
A highly selective kappa-opioid receptor agonist with low addictive potential and dependence liability.
Kaist
Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).
Bristol-Myers Squibb Pharmaceutical Research Institute
Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors.
Itherx Pharmaceuticals
Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores.
Boehringer Ingelheim Pharmaceuticals
Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis.
Korea Advanced Institute of Science and Technology
Discovery of new inhibitor for PDE3 by virtual screening.
Korea Research Institute of Chemical Technology
A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol.
Pusan National University
Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.
Washington University
Discovery of novel amidobenzimidazole derivatives as orally available small molecule modulators of stimulator of interferon genes for cancer immunotherapy.
Korea Research Institute of Chemical Technology
Discovery of N-benzylbenzamide-based allosteric inhibitors of Aurora kinase A.
Korea Institute of Science and Technology (KIST)
Discovery of Novel, Thienopyridine-Based Tyrosine Kinase Inhibitors Targeting Tumorigenic RON Splice Variants.
Wellmarkerbio Co.
Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis.
Yeungnam University
Identification of small molecule inhibitors against MMP-14 via High-Throughput screening.
University of Illinois at Chicago
Identification of (-)-Epigallocateshin gallate derivatives promoting innate immune activation via 2',3'-cyclic GMP-AMP-stimulator of interferon genes pathway.
Korea Institute of Science and Technology
Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.
Pusan National University
Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor.
Korea Research Institute of Chemical Technology
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors.
Korea Research Institute of Chemical Technology
Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity.
Cardiff University
Discovery of G Protein-Biased Antagonists against 5-HT
Korea Institute of Science and Technology
Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors.
Yonsei University
A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase).
Lgci
3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors.
Lgci
Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity.
Seoul National University
Design, Synthesis, and Biological Evaluation of New Peripheral 5HT
Gwangju Institute of Science and Technology
Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase).
University of Illinois At Chicago
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.
Sunchon National University
Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.
Seoul National University
Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling.
University of Illinois At Chicago
Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.
University of Illinois At Chicago
Bis-catechol-substituted redox-reactive analogues of hexamethonium and decamethonium: stimulated affinity-dependent reactivity through iron peroxide catalysis.
University of Toledo
Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant.
Korea Institute of Science and Technology (Kaist)
Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent.
Institut Pasteur Korea
Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions.
University of Illinois At Chicago
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.
Sunchon National University
Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists.
Korea Research Institute of Chemical Technology
t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.
Seoul National University
Synthesis and biological evaluation of largazole zinc-binding group analogs.
Duke University
3-CYCLIC AMINE-INDOLE DERIVATIVES AS SEROTONERGIC AGENTS FOR THE TREATMENT OF CNS DISORDERS
Mindset Pharma
Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof
Shanghai Institute of Materia Medica
Targeted drug rescue with novel compositions, combinations, and methods thereof
Exciva
6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
Purdue Research Foundation
Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives.
Nirma University
Epoxyeicosatrienoic acid analogs and methods of making and using the same
The Medical College of Wisconsin
DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.
Suntory Institute For Bioorganic Research
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
National Institute of Neurological Disorders and Stroke
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals