BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 745K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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14 articles for JT Mihalic

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.EBI
Amgen
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.EBI
Amgen
Discovery of a new class of ghrelin receptor antagonists.EBI
Amgen
Design and optimization of imidazole derivatives as potent CXCR3 antagonists.EBI
Amgen
Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.EBI
Amgen
Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists.EBI
Amgen
3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitorsBDB
Merck Sharp & Dohme
Bicyclic heteroaryl substituted compoundsBDB
Bristol-Myers Squibb
Structure of REV-ERBß ligand-binding domain bound to a porphyrin antagonist.BDB
The Scripps Research Institute
The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.BDB
Harvard Neurodiscovery Center
Discovery of a Highly Selective STK16 Kinase Inhibitor.BDB
Chinese Academy of Sciences
Inhibition of small ubiquitin-like modifier enzymes with substituted pyrrolo[2,3-b]quinoxalinesBDB
City of Hope
Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases.BDB
University of Wisconsin
Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.BDB
Leiden University