BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 745K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Donate Now

To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

Advanced Search

15 articles for J Deignan

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.EBI
Amgen
Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.EBI
Amgen
Structure-based design of novel inhibitors of the MDM2-p53 interaction.EBI
Amgen
Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.EBI
Amgen
Discovery of a new class of ghrelin receptor antagonists.EBI
Amgen
Design and optimization of imidazole derivatives as potent CXCR3 antagonists.EBI
Amgen
Discovery of potent and specific CXCR3 antagonists.EBI
Amgen
Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists.EBI
Amgen
3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitorsBDB
Merck Sharp & Dohme
Bicyclic heteroaryl substituted compoundsBDB
Bristol-Myers Squibb
Structure of REV-ERBß ligand-binding domain bound to a porphyrin antagonist.BDB
The Scripps Research Institute
The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.BDB
Harvard Neurodiscovery Center
Discovery of a Highly Selective STK16 Kinase Inhibitor.BDB
Chinese Academy of Sciences
Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases.BDB
University of Wisconsin
Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.BDB
Leiden University