39 articles for P Fan
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
Genentech
Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.
Amgen
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Amgen
Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.
Amgen
Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.
Daiichi Sankyo
Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.
Amgen
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.
Amgen
Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.
Northeastern University
Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
Amgen
Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Amgen
C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.
National Hellenic Research Foundation
Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase-6.
University of California
Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect.
Northwest University
Structural modifications of the cannabinoid side chain towards C3-aryl and 1',1'-cycloalkyl-1'-cyano cannabinoids.
National Hellenic Research Foundation
Research progress in biological activities of isochroman derivatives.
Shaanxi University of Chinese Medicine
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
Merck
Indole-Diterpenoids with Protein Tyrosine Phosphatase Inhibitory Activities from the Marine-Derived Fungus
Hebei University
Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.
University of Connecticut
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.
University of Connecticut
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.
University of Connecticut
Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.
University of Connecticut
Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues.
University of Hawaii
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
Gilead Sciences
Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.
University of Connecticut
High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor.
Northeastern University
Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species.
Florida A and M University
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
Genentech
1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte
Quinazolinones that inhibit the formation of tau oligomers and their method of use
Oligomerix
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
Tes Pharma