53 articles for T Takahashi
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Article Title
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Design and synthesis of curcumin derivatives as tau and amyloidß dual aggregation inhibitors.
Doshisha University
Development of dual targeting inhibitors against aggregations of amyloid-ß and tau protein.
Tokyo Institute of Technology
Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.
Kyowa Hakko Kirin
Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1.
Toray Industries
Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists.
Toray Industries
Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
Tsukuba Research Institute
5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.
F. Hoffmann-La Roche
Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition.
Astellas Pharma
Synthesis and structure-activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists.
Astellas Pharma
Conformationally restricted analog and biotin-labeled probe based on beauveriolide III.
Tohoku University
Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands.
National Institute of Health Sciences
Syntheses of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1.
University of Shizuoka
Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.
Kinki University
(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
Taisho Pharmaceutical
Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors.
Kyoto University
Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors.
Kyoto University
Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.
Tsukuba Research Institute
Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
Tsukuba Research Institute
Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds.
Tsukuba Research Institute
Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists.
Astellas Pharma
Synthesis, structure-activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H(3) receptor inverse agonists.
Tsukuba Research Institute
Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.
Tsukuba Research Institute
Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
Tsukuba Research Institute
Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.
Astellas Pharma
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.
Tsukuba Research Institute
Discovery of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent and selective heparanase-1 inhibitor utilizing an improved synthetic approach.
Taisho Pharmaceutical Co, Ltd
Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor.
Taisho Pharmaceutical
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compounds.
Shionogi
Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor.
Taisho Pharmaceutical Co.
Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors.
Taisho Pharmaceutical
Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors.
Taisho Pharmaceutical
Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors.
Taisho Pharmaceutical
Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition.
Taisho Pharmaceutical
Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists.
Tsukuba Research Institute
Design and synthesis of the potent, orally available, brain-penetrable arylpyrazole class of neuropeptide Y5 receptor antagonists.
Tsukuba Research Institute
Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD).
Mitobridge
Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon.
National Institute of Health Sciences
Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.
Kyushu University
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.
Daiichi Sankyo
Synthesis of fluorescent-labeled aeruginosin derivatives for high-throughput fluorescence correlation spectroscopy assays.
Graduate School of Science and Engineering
Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing.
Mitobridge
Structure-activity relations of rosmarinic acid derivatives for the amyloid β aggregation inhibition and antioxidant properties.
Muroran Institute of Technology
Design and synthesis of novelδ opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration.
Nippon Chemiphar
Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities.
Kitasato University
[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof
Zhuhai United Laboratories Co.
Substituted pyridines as DNMT1 inhibitors
Glaxosmithkline Intellectual Property Development
Tetrahydroquinoline-based bromodomain inhibitors
St. Jude Children'S Research Hospital
Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
Merck Sharp & Dohme