33 articles for GM Keserű
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
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Article Title
Organization
Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications.
Gedeon Richter
The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.
Gedeon Richter
4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate.
Gedeon Richter
Cell-based and virtual fragment screening for adrenergica2C receptor agonists.
Gedeon Richter Plc., Gy�Mroi�T 19-21, Budapest H-1103, Hungary.
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization.
Gedeon Richter
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: hit-to-lead optimization.
Gedeon Richter
Multiple fragment docking and linking in primary and secondary pockets of dopamine receptors.
Gedeon Richter
Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors.
Gedeon Richter
Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs.
Gedeon Richter
Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.
Gedeon Richter
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists.
Gedeon Richter
Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.
Gedeon Richter
Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.
Semmelweis University
Hit-to-lead optimization of pyrrolo[1,2-a]quinoxalines as novel cannabinoid type 1 receptor antagonists.
Gedeon Richter
Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile.
Gedeon Richter
Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.
University of Ljubljana
Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors.
Hun-Ren Research Centre for Natural Sciences
An electrophilic warhead library for mapping the reactivity and accessibility of tractable cysteines in protein kinases.
Research Centre For Natural Sciences
Designed Peptide Inhibitors of STEP Phosphatase-GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats.
Institute of Biochemistry of The Romanian Academy
Fragment-Based Optimization of Dihydropyrazino-Benzimidazolones as Metabotropic Glutamate Receptor-2 Positive Allosteric Modulators against Migraine.
Gedeon Richter
Discovery of selective fragment-sized immunoproteasome inhibitors.
Hungarian Academy of Sciences
Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs).
Gedeon Richter
Discovery of a novel kinase hinge binder fragment by dynamic undocking.
Universitat De Barcelona
Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H
Universidade Federal De S£O Paulo
The impact of binding site waters on the activity/selectivity trade-off of Janus kinase 2 (JAK2) inhibitors.
Hungarian Academy of Sciences
Fragment Based Optimization of Metabotropic Glutamate Receptor 2 (mGluR2) Positive Allosteric Modulators in the Absence of Structural Information.
Gedeon Richter
Discovery of d-amino acid oxidase inhibitors based on virtual screening against the lid-open enzyme conformation.
Hungarian Academy of Sciences
Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors.
Hungarian Academy of Sciences