32 articles for S Yamada
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
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Article Title
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Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds.
Rikkyo University
Identification of Novel D-Aspartate Oxidase Inhibitors by in Silico Screening and Their Functional and Structural Characterization in Vitro.
Kitasato University
Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists.
Okayama University Graduate School of Medicine
Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor.
Rikkyo University
Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports.
Hokkaido University
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.
Okayama University Graduate School of Medicine
Flexible ligand recognition of peroxisome proliferator-activated receptor-gamma (PPARgamma).
Rikkyo University
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.
TBA
2-Methylene 19-nor-25-dehydro-1alpha-hydroxyvitamin D3 26,23-lactones: synthesis, biological activities and molecular basis of passive antagonism.
Tokyo Medical and Dental University
22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor.
Tokyo Medical and Dental University
Usabamycins A-C: new anthramycin-type analogues from a marine-derived actinomycete.
Nippon Suisan Kaisha
Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers.
TBA
Fluorescent retinoid X receptor ligands for fluorescence polarization assay.
Okayama University
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation.
Okayama University
Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy.
Hokkaido University
Lorneic acids, trialkyl-substituted aromatic acids from a marine-derived actinomycete.
Nippon Suisan Kaisha
Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.
Hokkaido University
An aromatic moiety is not essential for pharmacophore binding to sigma binding sites: Synthesis of N-alkylazacycloheptane derivatives as potent sigma ligands
TBA
Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: cyclopropane-based conformationally restricted analogs of haloperidol.
Hokkaido University
Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism.
Tokyo Medical and Dental University
Ligand Screening System for the RXRα Heterodimer Using the Fluorescence RXR Agonist CU-6PMN.
University of Shizuoka
Structure-activity relationships of 19-norvitamin D analogs having a fluoroethylidene group at the C-2 position.
Tokyo Medical and Dental University
Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure.
Hokkaido University
Vitamin D receptor: ligand recognition and allosteric network.
Tokyo Medical and Dental University
Convenient Retinoid X Receptor Binding Assay Based on Fluorescence Change of the Antagonist NEt-C343.
Okayama University Graduate School of Medicine
Discovery of a "Gatekeeper" Antagonist that Blocks Entry Pathway to Retinoid X Receptors (RXRs) without Allosteric Ligand Inhibition in Permissive RXR Heterodimers.
Okayama University Graduate School of Medicine
Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure.
Hokkaido University
Creation of Fluorescent RXR Antagonists Based on CBTF-EE and Application to a Fluorescence Polarization Binding Assay.
Okayama University Graduate School of Medicine
Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.
Okayama University Graduate School of Medicine
Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand.
University of Shizuoka