BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.5M data for 728K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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15 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Synthesis and activity of novel 16-dehydropregnenolone acetate derivatives as inhibitors of type 1 5a-reductase and on cancer cell line SK-LU-1.EBI
Universidad Nacional Aut£Noma De M£Xico
Effect of dehydroepiandrosterone derivatives on the activity of 5a-reductase isoenzymes and on cancer cell line PC-3.EBI
National University of Mexico
Conformational analysis of an anti-androgenic, (E,E)-8-hydroxygermacrene B, using NOESY and dynamic NMR spectroscopy.EBI
Naresuan University
Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors.EBI
Saarland University
Pharmacological options in the treatment of benign prostatic hyperplasia.EBI
Pfizer
Indole derivatives as a new class of steroid 5 alpha-reductase inhibitors.EBI
Kyowa Hakko Kogyo
Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.EBI
Glaxo Inc. Research Institute
Structure activity relationship study of known inhibitors of the enzyme 5 alpha-reductase (5AR).EBI
Kingston University
 
The preparation and evaluation of (+/-)-trans-1-Diazo-8-methoxy-4a-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-2-one as an inhibitor of human type-1 steroid 5α-reductaseEBI
TBA
 
Synthesis of a chemiluminescent probe useful for the purification of steroid 5α-reductaseEBI
TBA
Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.EBI
Saarland University
Recent advances on synthesis and biological activities of C-17 aza-heterocycle derived steroids.EBI
Changzhi University
N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I and II inhibitory activity.EBI
UniversitäT Des Saarlandes
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.EBI
Bristol-Myers Squibb
Activity of steroid 4 and derivatives 4a-4f as inhibitors of the enzyme 5α-reductase 1.EBI
Universidad Nacional Aut£Noma De M£Xico