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BindingDB contains 2.6M data for 1.1M Compounds and 8.9K Targets. Of those, 1,167K data for 538K Compounds and 4.4K Targets were curated by BindingDB curators.

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86 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Pyridopyrimidinone inhibitors of HIV-1 RNase H.EBI
GlaxoSmithKline
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.EBI
Boehringer Ingelheim (Canada)
4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.EBI
National Institutes of Health
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.EBI
South China Normal University
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.EBI
University of Lille
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.EBI
Boehringer Ingelheim (Canada) Ltd
A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.EBI
Universit£ di Messina
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.EBI
Sapienza University of Rome
Application of CoMFA and CoMSIA 3D-QSAR and docking studies in optimization of mercaptobenzenesulfonamides as HIV-1 integrase inhibitors.EBI
University of Southern California
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.EBI
University of Tennessee Health Science Center
Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.EBI
Bristol-Myers Squibb Co.
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.EBI
National Cancer Institute/NIH
Active site binding modes of HIV-1 integrase inhibitors.EBI
University of California
Developing a dynamic pharmacophore model for HIV-1 integrase.EBI
University of California
Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives.EBI
CNRS UMR 8532
Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication.EBI
University of California
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.EBI
Sapienza University of Rome
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.EBI
National Cancer Institute-Bethesda
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.EBI
National Cancer Institute-Bethesda
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.EBI
National Cancer Institute-Bethesda
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.EBI
National Cancer Institute-Bethesda
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.EBI
National Cancer Institute-Bethesda
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.EBI
University of Houston
Binding modes of two novel dinucleotide inhibitors of HIV-1 integrase.EBI
The University of Iowa
Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides.EBI
Institute of Science and Technology
Ring substituent effects on biological activity of vinyl sulfones as inhibitors of HIV-1.EBI
University of California
Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome.EBI
University of Southern California
Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.EBI
Graduate School of the Chinese Academy of Sciences
From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.EBI
Università di Sassari
Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring.EBI
Gilead Sciences Inc
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.EBI
Gilead Sciences Inc
Effect of substitution on novel tricyclic HIV-1 integrase inhibitors.EBI
Gilead Sciences Inc
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.EBI
Merck Research Laboratories
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.EBI
Sapienza University of Rome
Dynamic pharmacophore model optimization: identification of novel HIV-1 integrase inhibitors.EBI
University of Houston
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.EBI
Central Pharmaceutical Research Institute
Beta-diketo acids with purine nucleobase scaffolds: novel, selective inhibitors of the strand transfer step of HIV integrase.EBI
University of Georgia
HIV integrase inhibitors with nucleobase scaffolds: discovery of a highly potent anti-HIV agent.EBI
University of Georgia
Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase.EBI
University of Southern California
Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors.EBI
Jagiellonian University
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.EBI
Università di Messina
Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis.EBI
Université des Sciences et Technologies de Lille I
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.EBI
Merck Research Laboratories
Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors.EBI
University of California
Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.EBI
Tibotec BVBA
Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors.EBI
University of Houston
New approaches toward anti-HIV chemotherapy.EBI
Katholieke Universiteit Leuven
Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.EBI
National Cancer Institute-Frederick
HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.EBI
Italy. Vinc
Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.EBI
Università di Sassari
Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase.EBI
Institute of Materia Medica
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.EBI
CNRS UMR 8076
6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays.EBI
Sapienza University of Rome
Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.EBI
NCI-Frederick
Catechol-substituted L-chicoric acid analogues as HIV integrase inhibitors.EBI
Institute of Science & Technology
Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.EBI
NIH
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.EBI
National Cancer Institute-Bethesda
Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.EBI
Purdue University
Four novel bis-(naphtho-gamma-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase.EBI
Merck Research Laboratories
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.EBI
Merck Research Laboratories
Metal-dependent inhibition of HIV-1 integrase.EBI
University of Southern California
Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives.EBI
Université des Sciences et Technologies de Lille
DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n).EBI
Russian Academy of Sciences
Synthesis and biological evaluation of bis-NEBI
Rhodes University
Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase.EBI
The University of Iowa
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase.EBI
"Sapienza" Universit£ di Roma
5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein.EBI
IRBM S.p.A.
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.EBI
Merck Research Laboratories
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.EBI
Bristol-Myers Squibb Research & Development
Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGF/p75 disruptors and inhibitors of microbial pathogens.EBI
University of the Witwatersrand
Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.EBI
Université Paris-Sud
Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity.EBI
Merck Research Laboratories
Thiazolothiazepine inhibitors of HIV-1 integrase.EBI
National Cancer Institute-Bethesda
Lamellarin alpha 20-sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture.EBI
Institute of Chemical Technology
Chicoric acid analogues as HIV-1 integrase inhibitors.EBI
National Cancer Institute-Bethesda
Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases.EBI
University of Iowa
Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.EBI
National Cancer Institute-Bethesda
Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.EBI
Paris-Sud University
Arylamide inhibitors of HIV-1 integrase.EBI
National Cancer Institute-Bethesda
Hydrazide-containing inhibitors of HIV-1 integrase.EBI
National Cancer Institute-Bethesda
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.EBI
National Cancer Institute-Bethesda
Coumarin-based inhibitors of HIV integrase.EBI
National Cancer Institute-Bethesda
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.EBI
Freie Universität Berlin
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.EBI
Purdue University
Hydroxylated aromatic inhibitors of HIV-1 integrase.EBI
National Cancer Institute-Bethesda
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.BDB
Daiichi Pharmaceutical