12 articles for DS Clarke
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.
Astrazeneca
Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.
Astrazeneca
Conformational restriction in a series of GPR119 agonists: differences in pharmacology between mouse and human.
Astrazeneca
Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.
Astrazeneca
Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life.
Astrazeneca R&D
Design of dual-acting thromboxane antagonist-synthase inhibitors by a mutual prodrug approach
TBA
Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.
Astrazeneca
A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase.
Astrazeneca
Quinuclidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase: optimization from lipid profiles.
Zeneca Pharmaceuticals
Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.
Zeneca Pharmaceuticals