BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 760K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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12 articles for LR Roberts

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Cmpds
Data
Article Title
Organization
14
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors.EBI
Pfizer
7
Kappa agonist CovX-Bodies.EBI
Pfizer
27
Novel 2-imidazoles as potent and selective alpha1A adrenoceptor partial agonists.EBI
Pfizer
4
SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives asµ opioid ligands.EBI
Pfizer
16
Sulfonamides as selective oestrogen receptorß agonists.EBI
Pfizer
34
Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability.EBI
Pfizer
23
6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists.EBI
Pfizer
24
Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks.EBI
Pfizer
29
7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.EBI
Pfizer
17
Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists.EBI
Pfizer
4
Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands.EBI
National Cancer Institute-Frederick
4
Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity.EBI
National Cancer Institute-Frederick