BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 760K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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21 articles for J Wright

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Cmpds
Data
Article Title
Organization
7
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound.EBI
Vanderbilt University Medical Center
19
Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter.EBI
Vanderbilt University Medical Center
14
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors.EBI
Pfizer
43
HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase.EBI
Astrazeneca
19
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.EBI
Msd
23
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.EBI
Msd
23
Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.EBI
TBA
11
(-)-3 beta-Substituted ecgonine methyl esters as inhibitors for cocaine binding and dopamine uptake.EBI
University of Maryland
5
Synthesis of substituted 3-carbamoylecgonine methyl ester analogues: irreversible and photoaffinity ligands for the cocaine receptor/dopamine transporter.EBI
University of Maryland
6
Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake.EBI
University of Maryland
5
Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake.EBI
University of Maryland
17
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.EBI
Celgene
22
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.EBI
Celgene
28
Structure-activity relationship (SAR) of thea-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.EBI
Sunesis Pharmaceuticals
22
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.EBI
Sunesis Pharmaceuticals
21
Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.EBI
Ligand Pharmaceuticals
21
 
8-amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonistsEBI
TBA
10
 
Discovery of selective dopamine D3 ligands: II. 2-[4-[3-(4-aryl-1-piperazinyl)propoxy]phenyl]benzimidazole partial agonistsEBI
TBA
17
 
Discovery of selective dopamine D3 ligands: I. Dimeric 2-[4-(3-aminopropoxy)phenyl]benzimidazole antagonistsEBI
TBA
2
Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.EBI
Glaxosmithkline
1
N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1.EBI
Glaxosmithkline