63 articles for L Wei
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.
Baylor College of Medicine
Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents.
University of Toronto
Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors.
Chinese Academy of Sciences
Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.
Pfizer
Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
California Nanosystems Institute
Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists.
Pfizer
Interrogation of the Active Sites of Protein Arginine Deiminases (PAD1, -2, and -4) Using Designer Probes.
University Health Network
Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model.
University Health Network
The design and synthesis of orally active short duration spiroindane growth hormone secretagogues
TBA
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Pfizer
Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.
University Health Network
Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1.
Genomics Institute of The Novartis Research Foundation
Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase.
University Health Network
Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase.
Toronto General Research Institute
Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives.
Guilford Pharmaceuticals
Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold.
Wichita State University
Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers.
Cytrx
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
Pfizer
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Pfizer
Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35.
Dalian Institute of Chemical Physics
α/Sulfono-γ-AApeptide Hybrid Analogues of Glucagon with Enhanced Stability and Prolonged In Vivo Activity.
University of South Florida
Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR.
University of South Florida
Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle.
Chinese Academy of Sciences
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
Pfizer
Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
Guilford Pharmaceuticals
Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase.
Anhui University of Technology
Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists.
Dalian Institute of Chemical Physics
Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides.
Guilford Pharmaceuticals
Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.
Central China Normal University
Design, synthesis and algicides activities of thiourea derivatives as the novel scaffold aldolase inhibitors.
International Cooperation Base of Pesticide and Green Synthesis (Hubei)
Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208.
Southeast University
Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.
Pfizer
Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects.
International Cooperation Base of Pesticide and Green Synthesis (Hubei)
Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus.
Beijing Institute of Pharmacology & Toxicology
SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins.
Stony Brook University
Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.
Duke University Medical Center
Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro.
China Pharmaceutical University
Synthesis and Biological Evaluation of a Series of Bile Acid Derivatives as FXR Agonists for Treatment of NASH.
Wuxi Apptec (Shanghai)
Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.
Pfizer
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.
Dalian Institute of Chemical Physics
Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.
Pfizer
Maslinic and oleanolic acids derivatives for treating SARS-CoV-2 infection
King Abdulaziz University
Ethyl N-boc piperidinyl pyrazolo pyridones as Janus kinase inhibitors
Merck Sharp & Dohme
Discovery of novel purine-based heterocyclic P2X7 receptor antagonists.
Gwangju Institute of Science and Technology
Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
Leo Pharma
Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
Merck Patent
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.
University of Toronto
Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.
University of Auckland