BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 756K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Donate Now

To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

Advanced Search

10 articles for J Burke

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.EBI
Boehringer Ingelheim Pharmaceuticals
Indole RSK inhibitors. Part 1: discovery and initial SAR.EBI
Boehringer Ingelheim Pharmaceuticals
Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity.EBI
Boehringer Ingelheim Pharmaceuticals
PDE-10A inhibitors as insulin secretagogues.EBI
Bayer Pharmaceuticals
Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders.EBI
University of Basel
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.EBI
Boehringer Ingelheim Pharmaceuticals
[1,2,4]triazolo[1,5-a]pyrimidin-7-yl compoundBDB
Janssen Pharmaceutica
5-HT2C receptor agonists and compositions and methods of useBDB
Arena Pharmaceuticals
Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue.BDB
Duquesne University
Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.BDB
Synaptic Pharmaceutical