9 articles for K Menear
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase.
Kudos Pharmaceuticals
The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.
Nagasaki International University
8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK).
Newcastle University
The design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors.
Novartis Horsham Research Centre
Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: ion-dipole interactions with lysine 60G.
Novartis Horsham Research Center
The discovery of orally available thrombin inhibitors: optimisation of the P1 pharmacophore.
Novartis Horsham Research Centre
Studies towards the identification of potent, selective and bioavailable thrombin inhibitors.
Novartis Horsham Research Center
The discovery of orally available thrombin inhibitors: studies towards the optimisation of CGH1668.
Novartis Horsham Research Center
Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states.
Institut De Recherches Servier