Binding Database

BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 745K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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16 articles for DJ Kopecky

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.

Amgen

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

Amgen

Discovery and optimization of a series of liver X receptor antagonists.

Amgen

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.

Amgen

Discovery of a new binding mode for a series of liver X receptor agonists.

Amgen

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.

Amgen

Discovery of

Amgen

Discovery of a Covalent Inhibitor of KRAS

TBA

3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors

Merck Sharp & Dohme

Pyridazine derivatives as RORc modulators

Genentech

Structure of REV-ERBß ligand-binding domain bound to a porphyrin antagonist.

The Scripps Research Institute

The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.

Harvard Neurodiscovery Center

New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives.

Universidade De Evora

Discovery of a Highly Selective STK16 Kinase Inhibitor.

Chinese Academy of Sciences

Inhibition of small ubiquitin-like modifier enzymes with substituted pyrrolo[2,3-b]quinoxalines

City of Hope

Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases.

University of Wisconsin