BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 745K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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25 articles for S Lai

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.EBI
Astex Pharmaceuticals
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.EBI
Amgen
Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.EBI
Amgen
Synthesis and structure-activity relationship of 2-arylamino-4-aryl-pyrimidines as potent PAK1 inhibitors.EBI
Astex Pharmaceuticals
Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.EBI
Amgen
Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.EBI
Amgen
Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives.EBI
Chinese Academy of Sciences
Discovery of AMG 853, a CRTH2 and DP Dual Antagonist.EBI
TBA
Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists.EBI
Millennium Pharmaceuticals
Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists.EBI
Abbott Laboratories
Identification of aminopiperidine benzamides as MCHr1 antagonists.EBI
Abbott Laboratories
Discovery of small molecule FLT3 inhibitors that are able to overcome drug-resistant mutations.EBI
Sichuan University
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.EBI
Amgen
5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties.EBI
Amgen
Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitorBDB
Incyte
3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitorsBDB
Merck Sharp & Dohme
Pyridazine derivatives as RORc modulatorsBDB
Genentech
Fused tricyclic ring derivatives as SRC homology-2 phosphatase inhibitorsBDB
Nikang Therapeutics
Bicyclic heteroaryl substituted compoundsBDB
Bristol-Myers Squibb
Benzothiazol compounds and methods using the same for treating neurodegenerative disordersBDB
1St Biotherapeutics
Structure of REV-ERBß ligand-binding domain bound to a porphyrin antagonist.BDB
The Scripps Research Institute
The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.BDB
Harvard Neurodiscovery Center
New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives.BDB
Universidade De Evora
Discovery of a Highly Selective STK16 Kinase Inhibitor.BDB
Chinese Academy of Sciences
Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. Evidence for a new mode of binding to aminopeptidases.BDB
University of Wisconsin