BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 745K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Donate Now

To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

Advanced Search

28 articles for JR Huff

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist.EBI
Merck Research Laboratories
Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide.EBI
Merck Research Laboratories
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.EBI
Merck Research Laboratories
HIV protease: a novel chemotherapeutic target for AIDS.EBI
Merck Sharp and Dohme Research Laboratories
 
Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN®EBI
TBA
 
2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptaseEBI
TBA
 
Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitorsEBI
TBA
 
Substituted alkylpyridines as P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors: Improved pharmacokinetic profilesEBI
TBA
 
Cyclic sulfone-3-carboxamides as novel P2-ligands for Ro 31-8959 based HIV-1 protease inhibitorsEBI
TBA
 
Conformationally constrained HIV-1 protease inhibitorsEBI
TBA
 
Synthesis and evaluation of pyridyl analogs of L-735,524: Potent HIV-1 protease inhibitorsEBI
TBA
 
A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailabilityEBI
TBA
 
Novel conformationally constrained HIV-1 protease inhibitors: rational design, enzyme inhibition, and X-ray structure of an enzyme-inhibtor complexEBI
TBA
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.EBI
Merck Research Laboratories
Nonpeptide alphavbeta3 antagonists. 8. In vitro and in vivo evaluation of a potent alphavbeta3 antagonist for the prevention and treatment of osteoporosis.EBI
Merck Research Laboratories
Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.EBI
Merck Research Laboratories
N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.EBI
Merck Research Laboratories
Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists.EBI
Merck
Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.EBI
Merck Research Laboratories
Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists.EBI
TBA
Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.EBI
TBA
Bioactive conformation of 1-arylpiperazines at central serotonin receptors.EBI
TBA
N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.EBI
TBA
Structure-affinity relationships of arylquinolizines at alpha-adrenoceptors.EBI
Merck Sharp & Dohme Research Laboratories
Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereofBDB
Jiangsu Hengrui Medicine
Amide compounds, compositions and applications thereofBDB
Advinus Therapeutics
2,4-disubstituted pyrimidines: a novel class of KDR kinase inhibitors.BDB
Merck Research Laboratories
Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR.BDB
Merck Research Laboratories