BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 756K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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23 articles for SJ Hughes

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.EBI
Biofocus
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.EBI
Pfizer
Fragment based discovery of a novel and selective PI3 kinase inhibitor.EBI
Pfizer
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.EBI
AstraZeneca
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.EBI
AstraZeneca
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.EBI
University of Dundee
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.EBI
Astrazeneca
Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.EBI
University of California Santa Cruz
DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines.EBI
Astrazeneca
Cot modulators and methods of use thereofBDB
Gilead Sciences
Pyrazole derivatives as MALT1 inhibitorsBDB
Janssen Pharmaceutica
Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including sameBDB
Korea Institute of Science and Technology
Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereofBDB
Chia Tai Tianqing Pharmaceutical Group
Azepine derivatives as 5-HT7 receptor modulatorsBDB
Korea Institute of Science and Technology
Tetrahydroisoquinoline derivatives, pharmaceutical compositions and uses thereofBDB
Boehringer Ingelheim International
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseasesBDB
Abbvie
Substituted benzothienopyrimidinesBDB
Bayer Pharma Aktiengesellschaft
Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.BDB
University of California Irvine
Substituted N-phenethyltriazoloneacetamides and use thereofBDB
Bayer Intellectual Property
Reactivators of organophosphorous inhibited acetylcholinesteraseBDB
Southwest Research Institute
Heterocyclic compounds containing an indole coreBDB
Boehringer Ingelheim International
Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5-Lipoxygenase Inhibitors.BDB
Hans Knöll Institute
3,5-disubstituted alkynylbenzene compound and salt thereofBDB
Taiho Pharmaceutical