16 articles for JP Guare
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors
TBA
A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability
TBA
Novel conformationally constrained HIV-1 protease inhibitors: rational design, enzyme inhibition, and X-ray structure of an enzyme-inhibtor complex
TBA
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Merck Research Laboratories
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
Merck Research Laboratories
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
Merck Research Laboratories
Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists.
Merck
Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines.
Merck Research Laboratories
L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.
Merck Research Laboratories
Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.
TBA
N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.
TBA
Structure-affinity relationships of arylquinolizines at alpha-adrenoceptors.
Merck Sharp & Dohme Research Laboratories
