39 articles for Q Lu
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.
Global Blood Therapeutics
Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities.
Chinese Academy of Sciences
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.
Glaxosmithkline
Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
Novartis Institutes For Biomedical Research
Syntheses of novel high affinity ligands for opioid receptors.
Rensselaer Polytechnic Institute
Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Rensselaer Polytechnic Institute
Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators).
Wyeth Research
Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation.
Scios
Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether.
Scios
Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 1: SAR of the aryl region.
Scios
Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone.
Rensselaer Polytechnic Institute
Shikonin derivatives: synthesis and inhibition of human telomerase.
Chinese Academy of Science
The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
Novartis Institutes For Biomedical Research
Discovery of potent dipeptidyl peptidase IV inhibitors derived fromß-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes.
Shandong University of Traditional Chinese Medicine
Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).
Novartis Institutes For Biomedical Research
Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
China Pharmaceutical University
Piperidine-based heterocyclic oxalyl amides as potent p38alpha MAP kinase inhibitors.
Scios
Design and synthesis of piperazine-indole p38alpha MAP kinase inhibitors with improved pharmacokinetic profiles.
Scios
Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
Glaxosmithkline
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 7: syntheses and opioid receptor properties of cyclic variants of cyclazocine.
Rensselaer Polytechnic Institute
Development of de-novo coronavirus 3-chymotrypsin-like protease (3CLpro) inhibitors since COVID-19 outbreak: A strategy to tackle challenges of persistent virus infection.
Shaanxi University of Science & Technology
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats.
Cytokinetics, Inc.
Structure-Activity Relationship and Biological Investigation of a REV-ERBĪ±-Selective Agonist SR-29065 (
The Scripps Research Institute
Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer.
Yanbian University
Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling.
Dongguk University-Seoul
Perspective for Discovery of Small Molecule IL-6 Inhibitors through Study of Structure-Activity Relationships and Molecular Docking.
Dongguk University
Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2.
Wyeth Research
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Chinese Academy of Sciences
Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1.
Zhejiang University
Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.
The Ohio State University
Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors.
The Ohio State University
Design, synthesis and identification of silicon-containing HCV NS5A inhibitors with pan-genotype activity.
Chia Tai Tianqing Pharmaceutical Group
MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF
Insilico Medicine IP
INHIBITOR OF RECEPTOR-INTERACTING PROTEIN KINASE 1, AND PREPARATION METHOD AND USE THEREFOR
China Pharmaceutical University
Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
Merck Sharp & Dohme