BDBM274241 5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 38

SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C)c2ccc(Cl)cc2)c2cc(Cl)c(=O)n(C)c2)c(OC)n1

InChI Key InChIKey=IFFAPYISKKZOPO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274241   

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandPNGBDBM274241(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50: 47nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [60-463](Human)
Novartis

US Patent
LigandPNGBDBM274241(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50: 322nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM274241(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50: 59nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM274241(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50: 205nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent