BDBM656647 2-((4-(7-(((2S,5R)-5-(3- (cyclopropylmethyl)ureido)tetrahydro-2H-pyran-2- yl)methyl)-2,7-diazaspiro[3.5]nonan-2- yl)pyrimidin-5-yl)oxy)-N-ethyl-5-fluoro-N- isopropylbenzamide::US11919901, Compound 42

SMILES CCN(C(C)C)C(=O)c1cc(F)ccc1Oc1cncnc1N1CC2(C1)CCN(C[C@@H]1CC[C@H](CO1)NC(=O)NCC1CC1)CC2

InChI Key InChIKey=LPPRDZVYQRJOOO-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 656647   

TargetMenin(Human)
Syndax Pharmaceuticals

US Patent
LigandPNGBDBM656647(2-((4-(7-(((2S,5R)-5-(3- (cyclopropylmethyl)ureido...)
Affinity DataIC50: 100nMAssay Description:For IC50 determination test compounds were prepared as 10 mM DMSO stock solutions. Considering DMSO as the vehicle in the assay system. Lower sub-sto...More data for this Ligand-Target Pair
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Date in BDB:
5/17/2024
Entry Details
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TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Syndax Pharmaceuticals

US Patent
LigandPNGBDBM656647(2-((4-(7-(((2S,5R)-5-(3- (cyclopropylmethyl)ureido...)
Affinity DataKi:  1.25nMAssay Description:Table 4: For Ki determination, individual compounds were prepared as 10 mM DMSO stock solutions. Considering DMSO as the vehicle in the assay system....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
Go to US Patent