BDBM10298 1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione::Isatin analog 2

SMILES O=C1N(Cc2ccccc2)c2ccc(cc2C1=O)N(=O)=O

InChI Key InChIKey=KRWGZAGTABTYNO-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 10298   

TargetCaspase-3(Human)
Glaxosmithkline

LigandChemical structure of BindingDB Monomer ID 10298BDBM10298(1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  130nM ΔG°:  -9.54kcal/mole IC50: 250nMpH: 7.5 T: 2°CAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed