BDBM12082 ((2-chloro-5-methyl-phenyl)-{6-[4-(3-(dimethylamino)-2-hydroxy-propoxy)-phenylamino]-pyrimidin-4-yl}-amino)-acetonitrile::2-[(2-chloro-5-methylphenyl)[6-({4-[(2R)-3-(dimethylamino)-2-hydroxypropoxy]phenyl}amino)pyrimidin-4-yl]amino]acetonitrile::AZ2

SMILES CN(C)C[C@@H](O)COc1ccc(Nc2cc(ncn2)N(CC#N)c2cc(C)ccc2Cl)cc1

InChI Key InChIKey=FIRZNFNHYVXQPP-LJQANCHMSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 12082   

TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM12082(((2-chloro-5-methyl-phenyl)-{6-[4-(3-(dimethylamin...)
Affinity DataIC50:  2.60E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 12.5 uM ATP/ [ga...More data for this Ligand-Target Pair
TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2 [K89T](Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM12082(((2-chloro-5-methyl-phenyl)-{6-[4-(3-(dimethylamin...)
Affinity DataIC50:  140nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 12.5 uM ATP/ [ga...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM12082(((2-chloro-5-methyl-phenyl)-{6-[4-(3-(dimethylamin...)
Affinity DataIC50:  47nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 12.5 uM ATP/ [ga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2 [F82H,L83V,H84D,K98T](Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM12082(((2-chloro-5-methyl-phenyl)-{6-[4-(3-(dimethylamin...)
Affinity DataIC50:  640nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 12.5 uM ATP/ [ga...More data for this Ligand-Target Pair
TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2 [F82H,L83V,H84D](Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM12082(((2-chloro-5-methyl-phenyl)-{6-[4-(3-(dimethylamin...)
Affinity DataIC50:  7.30E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 12.5 uM ATP/ [ga...More data for this Ligand-Target Pair