BDBM159756 PF-02384554::US10966980, Example 8::US9035074, 8

SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)c1cc(ccn1)C#N)c1ncnc2[nH]ccc12

InChI Key InChIKey=YHOLAGDZXSDDPR-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 159756   

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 2.70nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 38nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 43nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 260nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 605nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 700nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

LigandPNGBDBM159756(PF-02384554 | US9035074, 8 | US10966980, Example 8)
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed