BDBM174006 US9688661, 5-(6-Aminopyrimidin-4-yl)-2-[2-ethyl-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide (compd 218)

SMILES CCc1ccc(cc1-c1nc(cc1C(N)=O)-c1cc(N)ncn1)C(F)(F)F

InChI Key InChIKey=MDWOEQTVVNMKGB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 174006   

TargetTyrosine-protein kinase JAK1 [861-1152](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174006(US9688661, 5-(6-Aminopyrimidin-4-yl)-2-[2-ethyl-5-...)
Affinity DataIC50:  33nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174006(US9688661, 5-(6-Aminopyrimidin-4-yl)-2-[2-ethyl-5-...)
Affinity DataIC50:  54nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174006(US9688661, 5-(6-Aminopyrimidin-4-yl)-2-[2-ethyl-5-...)
Affinity DataIC50:  4nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent