BDBM174006 US9688661, 5-(6-Aminopyrimidin-4-yl)-2-[2-ethyl-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide (compd 218)
SMILES CCc1ccc(cc1-c1nc(cc1C(N)=O)-c1cc(N)ncn1)C(F)(F)F
InChI Key InChIKey=MDWOEQTVVNMKGB-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 174006
TargetTyrosine-protein kinase JAK1 [861-1152](Homo sapiens (Human))
Nerviano Medical Sciences
US Patent
Nerviano Medical Sciences
US Patent
Affinity DataIC50: 33nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Homo sapiens (Human))
Nerviano Medical Sciences
US Patent
Nerviano Medical Sciences
US Patent
Affinity DataIC50: 54nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair