BDBM174024 US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(9H-purin-6-yl)-1H-pyrrole-2-carboxamide (compd 245)

SMILES NC(=O)c1cc(cn1-c1cc(ccc1Cl)C(F)(F)F)-c1ncnc2[nH]cnc12

InChI Key InChIKey=ZMEBQCWGPNPVIQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 174024   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174024(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50:  27nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [861-1152](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174024(US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-...)
Affinity DataIC50:  386nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent