BDBM18626 (18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent-2-en-2-yl]thiophen-2-yl}methylidene)-17-oxa-6-azatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2(7),3,8,11,13,15-heptaen-13-ol::Alkene, 29

SMILES CC\C=C(/C)c1ccsc1\C=C1/Oc2ccc(O)c(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key InChIKey=CAVTYMQSFAIXRJ-AKXZRBJUSA-N

Data  4 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18626   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  4.40nM ΔG°:  -10.6kcal/mole IC50:  6.10nM EC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  42nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  57nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  346nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed