BDBM18627 (10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-5-one::Mifeprex::Mifepristone::RU-486::RU486 (tetramethyl-rhodamine conjugated)
SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C
InChI Key InChIKey=VKHAHZOOUSRJNA-GCNJZUOMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 192 hits for monomerid = 18627
Affinity DataEC50: 0.600nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.10nM EC50: 4.80nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Affinity DataKd: 2.00E+4nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Inhibition of antagonist activity towards Androgen receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against progesterone stimulated alkaline phosphatase activity in T47D human breast carcinoma cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Dexamethasone binding to Glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)More data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Displacement of [3H]mibolerone from human Androgen receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Antagonistic potency to the human progesterone receptor measured in the T-47D alkaline phosphatase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human Androgen receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonistic activity against human androgen receptor (hAR) in co-transfected CV-1 cells.More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:In vitro antagonist activity against human progesterone receptor isoform B(hPR-B) in mammalian(CV-1) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at GR assessed as NF-kappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Activity at GR assessed as ability to antagonize dexamethasone-induced MMTV luciferase reporter gene transactivation in human A549 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of fluorescent-labeled Dexamethasone binding to GRMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0280nMAssay Description:In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.298nMAssay Description:Antagonist activity against glucocorticoid receptor (unknown origin) expressed in HEK293 cells by GRE-dependent luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity against glucocorticoid receptor in rat H4-IIE cells assessed as inhibition of dexamethasone-induced receptor transactivation pre-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against progesterone induced PRE-luciferase activity in CV-cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Antagonist activity against PR beta-mediated transactivation of MMTV luciferase reporter gene in BacMam transduced progesterone-stimulated CV1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Binding affinity to glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexametha...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Antagonist activity at progesterone receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 6.31nMAssay Description:Antagonist activity at GR in human A549 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition of dexamethasone-induce...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of 3 nM [3H]R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Binding affinity against progesterone receptor using human T47D breast carcinoma cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase report...More data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at human glucocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter ...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by lucifer...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human androgen receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter gene a...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human androgen receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
Affinity DataEC50: 872nMAssay Description:Agonist activity at human glucocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells co-transfected with MMTV-Luc assessed as effect on p...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human progesterone receptor B expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of antagonist activity towards glucocorticoid (hGR) receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of antagonist activity towards mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of prednisilone-induced tyrosine aminotransferase (TAT) activity in rat hepatocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of [3H]dexamethasone binding to human glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of dexamethasone-induced glucocorticoid receptor mediated alkaline phosphatase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of dexamethasone-induced glucocorticoid receptor mediated tyrosine aminotransferase in rat hepatocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of glucocorticoid receptor Dexamethasone response in reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of dexamethasone-induced GR-mediated tyrosine amino transferase activity in rat hepatocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0450nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0210nMAssay Description:Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition...More data for this Ligand-Target Pair