BDBM19352 2,4-diaminopyrimidine-based antagonist, 7::6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-1H-1,3-benzodiazol-5-yl}pyrimidine-2,4-diamine

SMILES CCc1nc(N)nc(N)c1-c1ccc2n(Cc3ccc(cc3)S(C)(=O)=O)cnc2c1

InChI Key InChIKey=LSEHXMWYQVYWPQ-UHFFFAOYSA-N

Data  1 IC50  1 EC50  1 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19352   

TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19352(6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-1H-...)
Affinity DataIC50: 4nM EC50:  11nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Human)
Abbott Laboratories

LigandPNGBDBM19352(6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-1H-...)
Affinity DatapH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
In DepthDetails Article
PubMed