BDBM202780 US10245267, Example 127::US10709712, Example 127::US9242969, 127::US9694016, 127

SMILES COc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C

InChI Key InChIKey=BSUIIPUXGLKINZ-UHFFFAOYSA-N

Data  16 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 202780   

LigandChemical structure of BindingDB Monomer ID 202780BDBM202780(US9694016, 127 | US9242969, 127 | US10245267, Exam...)
Affinity DataIC50: 0.310nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202780BDBM202780(US9694016, 127 | US9242969, 127 | US10245267, Exam...)
Affinity DataIC50: 0.310nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202780BDBM202780(US9694016, 127 | US9242969, 127 | US10245267, Exam...)
Affinity DataIC50: 0.400nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202780BDBM202780(US9694016, 127 | US9242969, 127 | US10245267, Exam...)
Affinity DataIC50: 0.400nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202780BDBM202780(US9694016, 127 | US9242969, 127 | US10245267, Exam...)
Affinity DataIC50: 0.760nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 202780BDBM202780(US9694016, 127 | US9242969, 127 | US10245267, Exam...)
Affinity DataEC50:  250nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2019
Entry Details Article
PubMed