BDBM225527 GTC000233A

SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F

InChI Key InChIKey=LLBDUMUPBVPAMJ-UHFFFAOYSA-N

Data  90 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 90 hits for monomerid = 225527   

TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.61nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.75nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 4.26nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.94nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.54nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.59nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 5.27nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 6.90nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.74nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.04nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.48nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 4.02nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 8.13nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 4.75nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 6nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 5.38nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.62nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.85nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.32nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.55nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.39nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.91nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.61nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.60nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.92nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.68nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.27nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 4.05nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.78nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.60nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 4.15nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.42nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.03nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 7.19nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 6.58nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.05nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.66nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.5nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.62nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.96nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.26nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.24nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 4.58nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.01nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 2.39nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.29nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.31nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.91nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 1.93nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
TargetSYK Kinase(Homo sapiens (Human))
D3R

LigandPNGBDBM225527(GTC000233A)
Show SMILES CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-2-28(17-5-3-4-16-14(17)10-23-27-16)19-15(21)11-22-20(26-19)25-13-7-6-12-9-24-31(29,30)18(12)8-13/h3-8,10-11,24H,2,9H2,1H3,(H,23,27)(H,22,25,26)
Affinity DataIC50: 3.53nMAssay Description:SYK assay_HTRFMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sidPDB
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