BDBM23447 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide::Chloramphenicol::Chlornitromycin::Chloromycetin

SMILES OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O

InChI Key InChIKey=WIIZWVCIJKGZOK-UHFFFAOYSA-N

Data  1 KI  5 IC50  1 EC50  3 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 23447   

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23447BDBM23447(Chloromycetin | 2,2-dichloro-N-[(1R,2R)-1,3-dihydr...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23447BDBM23447(Chloromycetin | 2,2-dichloro-N-[(1R,2R)-1,3-dihydr...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 23447BDBM23447(Chloromycetin | 2,2-dichloro-N-[(1R,2R)-1,3-dihydr...)
Affinity DataIC50: 9.58E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 0 hits for monomerid = 23447