BDBM26261 (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide::C-31::CHEMBL512283::US9278914, S-II

SMILES C[C@](O)(COc1ccc(Cl)c(F)c1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=SSFVOEAXHZGTRJ-KRWDZBQOSA-N

Data  2 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 26261   

TargetAndrogen receptor(Homo sapiens (Human))
Gtx

Curated by ChEMBL
LigandPNGBDBM26261((2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(tr...)
Affinity DataKi:  1.70nMAssay Description:Agonist activity at androgen receptor (unknown origin)More data for this Ligand-Target Pair
TargetAndrogen receptor(Rattus norvegicus (Rat))
The Ohio State University

LigandPNGBDBM26261((2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(tr...)
Affinity DataKi:  1.70nM ΔG°:  -11.1kcal/molepH: 7.4 T: 2°CAssay Description:The Ki values were determined by the application of the Cheng-Prusoff equation: Ki = (IC50 x Kd)/(Kd+[L]) where [L] is the concentration of [3H]MIB (...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Tennessee Research Foundation

US Patent
LigandPNGBDBM26261((2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(tr...)
Affinity DataIC50:  1.30E+3nMT: 2°CAssay Description:P450 enzyme inhibition was measured using human cDNA-expressed CYP3A4, 2D6, 2C19, 2C9, and 1A2 recombinant enzymes and fluorogenic substrates (coumar...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Tennessee Research Foundation

US Patent
LigandPNGBDBM26261((2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(tr...)
Affinity DataIC50: >2.00E+4nMT: 2°CAssay Description:P450 enzyme inhibition was measured using human cDNA-expressed CYP3A4, 2D6, 2C19, 2C9, and 1A2 recombinant enzymes and fluorogenic substrates (coumar...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Tennessee Research Foundation

US Patent
LigandPNGBDBM26261((2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(tr...)
Affinity DataIC50:  1.77E+4nMT: 2°CAssay Description:P450 enzyme inhibition was measured using human cDNA-expressed CYP3A4, 2D6, 2C19, 2C9, and 1A2 recombinant enzymes and fluorogenic substrates (coumar...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Tennessee Research Foundation

US Patent
LigandPNGBDBM26261((2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(tr...)
Affinity DataIC50: >2.00E+4nMT: 2°CAssay Description:P450 enzyme inhibition was measured using human cDNA-expressed CYP3A4, 2D6, 2C19, 2C9, and 1A2 recombinant enzymes and fluorogenic substrates (coumar...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Tennessee Research Foundation

US Patent
LigandPNGBDBM26261((2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(tr...)
Affinity DataIC50:  2.40E+3nMT: 2°CAssay Description:P450 enzyme inhibition was measured using human cDNA-expressed CYP3A4, 2D6, 2C19, 2C9, and 1A2 recombinant enzymes and fluorogenic substrates (coumar...More data for this Ligand-Target Pair
In DepthDetails US Patent