BDBM26292 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215275::pyrazoloquinazoline deriv., 26

SMILES CCN(CCO)CCCOc1cc2ncnc(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)c2cc1OC

InChI Key InChIKey=HOHHMYNNRAVKQB-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26292   

TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26292(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26292(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)
Affinity DataKi:  190nM ΔG°:  -9.16kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26292(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)
Affinity DataIC50:  270nMAssay Description:Inhibition of aurora B in human SW620 cells assessed as inhibition of histone H3 phosphorylationChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26292(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)
Affinity DataIC50:  190nMAssay Description:Inhibition of aurora A kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26292(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)
Affinity DataIC50:  1nMAssay Description:Inhibition of aurora B kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed