BDBM26293 CHEMBL217804::N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)(propyl)amino]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide::pyrazoloquinazoline deriv., 27

SMILES CCCN(CCO)CCCOc1cc2ncnc(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)c2cc1OC

InChI Key InChIKey=JCXULQAGBNATOH-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26293   

TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26293(CHEMBL217804 | N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-...)
Affinity DataKi:  2nM ΔG°:  -11.7kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26293(CHEMBL217804 | N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-...)
Affinity DataKi:  220nM ΔG°:  -9.08kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26293(CHEMBL217804 | N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-...)
Affinity DataIC50:  290nMAssay Description:Inhibition of aurora B in human SW620 cells assessed as inhibition of histone H3 phosphorylationChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26293(CHEMBL217804 | N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-...)
Affinity DataIC50:  220nMAssay Description:Inhibition of aurora A kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26293(CHEMBL217804 | N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of aurora B kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed