BDBM281889 3-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]methyl} amino)-N-[(1S)-1-(3,4- difluorophenyl)ethyl] pyrazine-2-carboxamide (TFA salt)::US10030016, Example 3.77

SMILES C[C@H](NC(=O)c1nccnc1NCc1ccc(s1)-c1ccc2ncnc(N)c2c1)c1ccc(F)c(F)c1

InChI Key InChIKey=COUAOHYRSDFGIK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281889   

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281889(3-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Affinity DataIC50: 100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
In DepthDetails
US Patent