BDBM367184 2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxamide::US10226452, Example 1

SMILES O=C(NCCCCc1ccccc1)n1c2ccccc2oc1=O

InChI Key InChIKey=OQMAVTWWUBRDJK-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 367184   

TargetAcid ceramidase(Homo sapiens (Human))
Argonne National Laboratory

Curated by ChEMBL
LigandPNGBDBM367184(2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxa...)
Affinity DataKi:  64nMAssay Description:Non-competitive inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
Argonne National Laboratory

Curated by ChEMBL
LigandPNGBDBM367184(2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxa...)
Affinity DataIC50:  64nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
Argonne National Laboratory

Curated by ChEMBL
LigandPNGBDBM367184(2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxa...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
Argonne National Laboratory

Curated by ChEMBL
LigandPNGBDBM367184(2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxa...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells preincubated for 30 mins followed by fluorogenic probe addition and measured after 3 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
Argonne National Laboratory

Curated by ChEMBL
LigandPNGBDBM367184(2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxa...)
Affinity DataIC50:  64nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent