BDBM400287 US10695337, Example 41::US11285140, Example 41::US9999619, Example 42

SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F

InChI Key InChIKey=WWXJDLQTHPTLSY-UHFFFAOYSA-N

Data  6 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 400287   

TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte Holdings Corporation

US Patent
LigandPNGBDBM400287(US10695337, Example 41 | US11285140, Example 41 | ...)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C26H24F2N8O/c27-21-3-1-2-19(22(21)28)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-20-4-9-30-24(20)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)
Affinity DataIC50: 10nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Holdings Corporation

US Patent
LigandPNGBDBM400287(US10695337, Example 41 | US11285140, Example 41 | ...)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C26H24F2N8O/c27-21-3-1-2-19(22(21)28)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-20-4-9-30-24(20)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Holdings Corporation

US Patent
LigandPNGBDBM400287(US10695337, Example 41 | US11285140, Example 41 | ...)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C26H24F2N8O/c27-21-3-1-2-19(22(21)28)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-20-4-9-30-24(20)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Holdings Corporation; Incyte Corporation

US Patent
LigandPNGBDBM400287(US10695337, Example 41 | US11285140, Example 41 | ...)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C26H24F2N8O/c27-21-3-1-2-19(22(21)28)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-20-4-9-30-24(20)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)
Affinity DataIC50: 10nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte Holdings Corporation

US Patent
LigandPNGBDBM400287(US10695337, Example 41 | US11285140, Example 41 | ...)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C26H24F2N8O/c27-21-3-1-2-19(22(21)28)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-20-4-9-30-24(20)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte Holdings Corporation

US Patent
LigandPNGBDBM400287(US10695337, Example 41 | US11285140, Example 41 | ...)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C26H24F2N8O/c27-21-3-1-2-19(22(21)28)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-20-4-9-30-24(20)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid