BDBM417432 6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4- yl}-2-[2-oxo-2-(2,3,4,5- tetrahydro-1H-2- benzazepin-2- yl)ethyl]-2,3-dihydro- 1H-isoindol-1-one::US10457669, Example 43::US11001575, Example 43

SMILES Clc1cnc(NC2CCOCC2)nc1-c1ccc2CN(CC(=O)N3CCCc4ccccc4C3)C(=O)c2c1

InChI Key InChIKey=IGCMZDAOWJBAOH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 417432   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417432(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4- yl}-...)
Affinity DataIC50: 14nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417432(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4- yl}-...)
Affinity DataIC50: 14nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417432(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4- yl}-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed