BDBM417753 2-[6-(5-chloro-2-{[3- (hydroxymethyl) oxetan-3- yl]amino}pyrimidin- 4-yl)-1-oxo-2,3- dihydro-1H- isoindol-2-yl]-N- [(1R)-1-(3- methoxyphenyl) ethyl]acetamide::US10457669, Example 383::US11001575, Example 383

SMILES COc1cccc(c1)[C@@H](C)NC(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC2(CO)COC2)ncc1Cl

InChI Key InChIKey=QVHZWSQEZSTYCM-MRXNPFEDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 417753   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417753(2-[6-(5-chloro-2-{[3- (hydroxymethyl) oxetan-3- yl...)
Affinity DataIC50:  1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent