BDBM418188 2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4-yl}-1-methoxy-3- oxo-2,3-dihydro-1H-isoindol-2-yl]-N- [(1S)-1-(3-fluoro-5-methoxyphenyl)-2- hydroxyethyl]acetamide::US10457669, Example 947::US11001575, Example 947

SMILES CO[C@H]1N(CC(=O)N[C@H](CO)c2cc(F)cc(OC)c2)C(=O)c2cc(ccc12)-c1nc(NC2CCOCC2)ncc1Cl

InChI Key InChIKey=AGDWIVRHHSVBNY-UFHPHHKVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418188   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418188(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50:  1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418188(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50:  1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent