BDBM418229 (2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4-yl{-1-oxo-2,3- dihydro-1H-isoindol-2-yl)-N-[(1S)-1-[5- fluoro-2-(4-methylpiperazin-1- yl)pyridin-4-yl]-2- hydroxyethyl]propanamide::US10457669, Example 996::US11001575, Example 996

SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1cc(ncc1F)N1CCN(C)CC1

InChI Key InChIKey=HJWQKLUNYJFMNC-XHCCPWGMSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 418229   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418229((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50:  1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418229((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50:  1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent